PSI Structural Biology Knowledgebase

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P2Y Receptors and Blood Clotting

PSI researchers have revealed a novel rearrangement in a purine-binding GPCR, opening new avenues for the design of blood clotting drugs.

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Research Advances

  • Drug Targets Bile Acids in Motion

    Drug Targets: Bile Acids in Motion
    Crystal structures of sodium-dependent bile acid transporters provide insight into transport mechanism.

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  • Drug Targets S1Rs Ligands and Partners

    Drug Targets: S1R's Ligands and Partners
    Stabilization of oligomers by small-molecule ligands suggests a mechanism for regulating a membrane protein chaperone.

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Technical Highlights

  • Complex Search

    Complex Search
    A search engine identifies assemblies with structural similarities, providing biologically relevant insights not accessible by comparison of individual proteins.

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  • Repairing a Rift

    Repairing a Rift
    Computational and crystallographic analyses identify new hybrid folds that fill gaps in existing structural space.

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