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Protein Folding and Misfolding

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Dynamic DnaK

PSI researchers have used an engineered version of DnaK to reveal the open state of an Hsp70 protein chaperone.

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Research Advances

  • Protein Folding and Misfolding A TRiCster that Follows the Rules

    Protein Folding and Misfolding: A TRiC-ster that Follows the Rules
    Experimental and computational techniques establish substrate recognition rules for the chaperonin TRiC.

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  • Protein Folding and Misfolding Beneficial Aggregation

    Protein Folding and Misfolding: Beneficial Aggregation
    The ERAD-associated lectin Yos9 forms aggregates in the presence of misfolded substrates.

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Technical Highlights

  • Protein Folding and Misfolding Refolding in Membrane Mimetic

    Protein Folding and Misfolding: Refolding in Membrane Mimetic
    Using a membrane mimetic system, researchers produce properly folded integral membrane proteins that are suitable for subsequent X-ray crystallography analysis.

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  • Protein Folding and Misfolding Its the Journey Not the Destination

    Protein Folding and Misfolding: It's the Journey, Not the Destination
    Computational analysis suggests ∼10% of pathogenic mutations interfere with membrane integration.

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