PSI Structural Biology Knowledgebase

PSI | Structural Biology Knowledgebase
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Research Themes
Cell biology
Drug discovery
Infectious diseases
Membrane proteins
Novel Proteins
Protein design
Protein-protein interactions

Technology Topics
Target Selection
Protein Expression
Electron Microscopy
Mass Spectrometry
Hybrid/Integrative Methods
Dissemination Tools

E-Collection Research Themes: Cancer

Related Articles

Cell Adhesion and Metastasis: DnaJ, Meet JNK

Featured Article - July 2014
A chaperone–cochaperone interaction suppresses the JNK pathway and provides a novel target for pancreatic cancer drug discovery.

Cell Adhesion and Metastasis: Unraveling Talin

Featured Article - July 2014
In the absence of a 3D crystal structure of talin, a structural model based on EM reconstruction and known structures of individual domains provides insight into its mechanism of action.

DNAJA1 and Pancreatic Cancer

Featured System - July 2014
PSI researchers have determined the structure of a DnaJ cochaperone and studied its role in pancreatic cancer.

Cancer Networks: IFI16-mediated p53 Activation

Featured Article - November 2013
Structural and functional analyses of the p53-binding HIN domains of IFI16 reveal their mechanism of action.

Cancer Networks: Predicting Catalytic Residues from 3D Protein Structures

Technical Highlight - November 2013
Identifying the structural features that can predict catalytic amino acids will enhance the functional assignment of unknown proteins in structural databases.

Cancer Networks: Solving a Tumor Suppressor Protein

Featured Article - November 2013
Structural characterization of CDK2AP1 reveals a disordered N-terminal region and a four-helix C-terminal domain.

G Proteins and Cancer

Featured System - November 2013
G-proteins play an essential role in cell signaling, a role that is corrupted in many types of cancer cells.

Cell-Cell Interaction: A FERM Connection

Featured Article - March 2013
The structure of a KRIT1–HEG1 complex reveals a new binding mechanism for FERM domains.

Cell-Cell Interaction: Modulating Self Recognition Affinity

Featured Article - March 2013
Subtle changes that distinguish homophilic and heterophilic interactions in a cell surface molecule are revealed.

Topping off the proteasome

Featured Article - March 2012
The structure of the entire proteasome complex provides insight into key functions while raising questions for future studies.


Featured Article - February 2012
A novel immunoglobulin ligand with functions in autoimmunity and cancer surveillance is characterized.

Rb Tumor Suppressor and Cancer

Featured System - August 2011
One of the overarching goals of structural genomics is to characterize the structure and function of entire systems of proteins.

A glimpse of NDRG2

Featured Article - April 2011
While the NDRG family has been implicated in a number of diseases and cancers, the molecular function of these factors remains unclear. The structures of NDRG2 reveal unusual features that give insight into these functions.

RBBP9 (Retinoblastoma Binding Protein 9)

Featured System - June 2010
Biological complexity is at its most complex when we look to signaling.

The cancer kinome

Featured Article - April 2010
Structural genomics has an important role to play in guiding development of specific anti-cancer drugs.

Click for cancer-protein interactions

Technical Highlight - December 2008
The Human Cancer Pathway Protein Interaction Network (HCPIN) website makes structural information about cancer-related proteins easily accessible.Mol. Cell. Proteomics 7, 2048-2060 (2008)
Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health