PSI Structural Biology Knowledgebase

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Cell biology
Drug discovery
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Membrane proteins
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Protein-protein interactions

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E-Collection Research Themes: Protein-protein interactions

Related Articles

Families in Gene Neighborhoods

Technical Highlight - June 2015
A bioinformatics strategy takes advantage of the proximal organization of genes encoding proteins involved in metabolic pathways to predict protein function.

Signaling: A Platform for Opposing Functions

Featured Article - May 2015
A modeled structure reveals the regulatory complexities of a TORC1-interacting complex.

Nuclear Pore Complex: A Flexible Transporter

Featured Article - February 2015
Structural flexibility in HEAT motifs enables proteins to pass through the nuclear pore complex.

Nuclear Pore Complex: Higher Resolution of Macromolecules

Technical Highlight - February 2015
Integrating mass spectrometry data for crosslinked oligomers reveals details of the yeast nuclear pore complex.

Nuclear Pore Complex: Integrative Approach to Probe Nup133

Featured Article - February 2015
The integration of three structural methods offers insight into membrane association of the NPC.

Piecing Together the Nuclear Pore Complex

Featured System - February 2015
PSI researchers have solved another piece in the puzzle for revealing an atomic-level model of the nuclear pore complex.

iTRAQing the Ubiquitinome

Technical Highlight - July 2014
An inflammatory signal triggers broad changes to protein ubiquitination and chromatin regulation in immune cells.

CAAX Endoproteases

Featured System - August 2013
Structures of two Ste24p-family proteases locate the active site inside a hollow, membrane-spanning chamber.

The Immune System: A Strong Competitor

Featured Article - June 2013
HLA-DO is an MHCII mimic that prevents the association of HLA-DM to MHCII.

The Immune System: Strand Swapping for T-Cell Inhibition

Featured Article - June 2013
An immunoglobulin protein with a role in antigen-independent T-cell signaling dimerizes via a strand-swapped interface.

PDZ Domains

Featured System - April 2013
PDZ domains are specialists in protein recognition, but PSI Biology researchers are revealing their abilities to bind to membranes as well.

Protein Interaction Networks: Adding Structure to Protein Networks

Technical Highlight - April 2013
Interactome3D is a tool and resource for annotating protein networks with three-dimensional structure information.

Protein Interaction Networks: Morph to Assemble

Featured Article - April 2013
The scaffold protein IscU alternates between structured and disordered conformations during iron-sulfur cluster assembly and delivery.

Protein Interaction Networks: Reading Between the Lines

Technical Highlight - April 2013
An additional separation is added to LC-MS to obtain more information about quaternary structure of complexes.

Protein Interaction Networks: When the Sum Is Greater than the Parts

Featured Article - April 2013
Integration of low-resolution approaches yields functional and evolutionary insights into the NPC.

Alpha-Catenin Connections

Featured System - March 2013
Structures of alpha-catenin and vinculin are revealing a highly dynamic interaction in adherens junctions.

Cytochrome Oxidase

Featured System - November 2012
Cytochrome oxidase is the foundation of aerobic respiration.

Bacterial Phosphotransferase System

Featured System - October 2012
Bacteria are thrifty cells.

Solute Channels

Featured System - September 2012
Cells maintain a steady traffic of small molecules across their membranes.

Budding ensemble

Featured Article - August 2012
An integration of several structural approaches has generated a model for how vesicle budding may be coordinated by ESCRT complexes.

The machines behind the spindle assembly checkpoint

Featured Article - June 2012
The crystal structure of the mitotic checkpoint complex is reported.

G Protein-Coupled Receptors

Featured System - May 2012
In the past five years, the field of GPCR structure has exploded.

Revealing the Nuclear Pore Complex

Featured System - March 2012
This is an exciting time for the study of the nuclear pore complex, the highway of transport between the cytoplasm and nucleus, and also a central player in nuclear organization and gene regulation.

Topping off the proteasome

Featured Article - March 2012
The structure of the entire proteasome complex provides insight into key functions while raising questions for future studies.

Anchoring's the way

Featured Article - February 2012
New insights into the regulation of AQP0 reveal mechanisms involved in cataract development.

Reading out regioselectivity

Featured Article - December 2011
The structures of four glycosyltransferases operating within a single biosynthetic pathway point to conserved and divergent mechanisms for controlling the regioselective addition of sugar donors, with implications for glycosyltransferase engineering.

An effective and cooperative dimer

Featured Article - November 2011
NMR studies reveal the dimer interface of the effector domain (ED) of NS1A from influenza A virus and provide insight into how dimerization of the ED provides cooperative dsRNA binding and other functions of NS1A.

PDZ domains: sometimes it takes two

Technical Highlight - November 2011
A systems approach reveals an unexpectedly high frequency of PDZ domain dimerization.

Raising a glass to GLIC

Featured Article - August 2011
The pentameric ligand-gated ion channels (pLGICs) are known to be affected by alcohol in eukaryotes. Analyses of the prokaryotic GLIC suggest that it may be a good structural model for the effects of n-alcohols on pLGICs.

A2A Adenosine Receptor

Featured System - May 2011
With proteins, small motions often have large effects.

A growing family

Technical Highlight - February 2011
Combining structural and computational methods helps to define a family of proteins.

FERM-ly bound

Technical Highlight - February 2011
X-ray crystallography of protein complex resolves a controversy regarding domain interactions.


Featured System - January 2011
The GPCR (G protein-coupled receptor) community is suffering from an embarrassment of riches.

Guard cells pick up the SLAC

Featured Article - December 2010
Guard cells rely on anion channels to regulate stomata in response to environmental cues. A new crystal structure gives insight into how stomata close.

Zinc Transporter ZntB

Featured System - July 2010
Zinc is an essential component of many cellular processes.

Zinc Transporter ZntB

Featured System - July 2010
Zinc is an essential component of many cellular processes.

Importance of extension for integrin

Featured Article - June 2010
An extended conformation of α5ß1 integrin is important for cell spreading and adhesion complex formation.

Spot protein-protein interactions… fast

Technical Highlight - March 2010
Nanowire transistors act as high-throughput biosensors for detecting protein interactions.

Alg13 Subunit of N-Acetylglucosamine Transferase

Featured System - February 2010
Eukaryotic cells have an elaborate mechanism for adding sugar chains to their proteins.

Urea transporter

Featured Article - February 2010
The X-ray crystal structure of a bacterial homolog of the mammalian urea transporter reveals a highly specific, channel-like transport mechanism.

Two-component signaling

Featured Article - December 2009
The structure of a sensor histidine kinase in complex with its effector response regulator reveals the details of the phosphoryl transfer reaction.

ABA receptor...this time for real?

Featured Article - November 2009
After years of controversy, two groups have independently identified the same receptor family for the plant stress hormone abscisic acid.

Network coverage

Featured Article - November 2009
A comprehensive atomic-resolution analysis of the centralmetabolic system of Thermotoga maritima sheds light on protein evolution.

Get3 into the groove

Featured Article - October 2009
Unlike most membrane proteins, SNAREs enter the endoplasmic reticulum after translation. The structure of the ATPase needed for entry reveals the likely mechanism.

Guanine Nucleotide Exchange Factor Vav1 and Rho GTPase Rac1

Featured System - October 2009
Our cells are filled with a cytoskeleton that provides an infrastructure for support, transport, and locomotion.

GPCR subunits: Separate but not equal

Featured Article - September 2009
A functional complementation assay reveals that maximal heterotrimeric G-protein activation is achieved by agonist binding to one subunit of a dopamine D2 receptor dimer.

Proofreading RNA

Featured Article - July 2009
The structure of RNA polymerase II caught in the 'backtracked' state reveals how it ensures faithful transcription.Science 324, 1203-1206 (2009)

Ribonuclease and Ribonuclease Inhibitor

Featured System - April 2009
The complex between ribonuclease and ribonuclease inhibitor is one of the tightest known intermolecular interactions, but researchers at the CESG are trying to change that.

The elusive helicase

Featured Article - April 2009
A combination of NMR, mutagenesis and biochemistry reveals the dynamic nature of the eIF4A/4G/4H helicase complex.Cell 136, 447-470 (2009)

Click for cancer-protein interactions

Technical Highlight - December 2008
The Human Cancer Pathway Protein Interaction Network (HCPIN) website makes structural information about cancer-related proteins easily accessible.Mol. Cell. Proteomics 7, 2048-2060 (2008)
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