PSI Structural Biology Knowledgebase

PSI | Structural Biology Knowledgebase
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Research Themes
Cell biology
Drug discovery
Infectious diseases
Membrane proteins
Novel Proteins
Protein design
Protein-protein interactions

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Protein Expression
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Mass Spectrometry
Hybrid/Integrative Methods
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E-Collection Research Themes: DNA and RNA

Related Articles

Cas4 Nuclease and Bacterial Immunity

Featured System - February 2014
A distinctive toroidal structure, a metal ion and an iron-sulfur cluster allow Cas4 to unwind and process phage DNA in the process of CRISPR-associated immunity.

Protein-Nucleic Acid Interaction: Inhibition Through Allostery

Technical Highlight - July 2013
NMR studies highlight the importance of investigating transitional species to fully understand protein function.

Stabilizing DNA Single Strands

Featured System - July 2013
PSI researchers have determined the structure of a new single-stranded DNA-binding domain, revealing a surprising connection between the kingdoms of life.

AlkB Homologs

Featured System - August 2012
Evolution is a great tinkerer, and when cells discover a useful plan for a protein, it is often pressed to service in other capacities.

Methyl maintenance

Featured Article - May 2012
A structure of a DNA methyltransferase complex highlights how autoinhibitory and active mechanisms ensure substrate selectivity.

Follow the RNA leader

Technical Highlight - December 2011
An NMR method characterizes an RNA structural switch that regulates HIV-1 genome packaging.

RNA Chaperone NMB1681

Featured System - July 2011
The small protein NMB1681 has been proposed to act as an RNA chaperone, but unlike a chaperone at a high school dance, NMB1681 acts as a molecular matchmaker, trying to bring together the molecules it watches over, rather than keeping them apart.

Seeing HetR

Featured Article - July 2011
The structure of the transcription factor HetR now indicates how it might function during cyanobacterial differentiatation.

Structure from sequence

Technical Highlight - July 2011
A new computational tool will allow researchers to easily predict RNA structural modules from the sequence alone.

Added benefits

Featured Article - April 2011
Biochemical, structural and genetic analyses reveal that the E. coli Cas1 protein YgbT belongs to a novel family of nucleases and that, in addition to antiviral immunity, the CRISPR–Cas system functions in DNA repair.

Nitrile Reductase QueF

Featured System - March 2011
Nature uses exotic chemistry to build its diverse collection of molecules.

Inhibiting factor

Featured Article - February 2011
Transcription initiation and elongation by RNA polymerase is inhibited by GreA. A recent crystal structure reveals the mechanism.

Tryptophanyl-tRNA Synthetase

Featured System - February 2011
Biology is full of surprises, and they often tell us important things about ourselves.

Regulating nitrogen assimilation

Featured Article - January 2011
By combining their efforts, researchers at two PSI centers provide new insights into a switch that controls nitrogen metabolism in microorganisms.

Subtle shifts

Featured Article - January 2011
The crystal structure of EF-Tu bound to the 70S ribosome solves a 40-year-old puzzle.

tRNA Isopentenyltransferase MiaA

Featured System - August 2010
Cells always seem to find the best way of doing things.

Mre11 Nuclease

Featured System - May 2010
All living things on the Earth store their genetic information in long strands of DNA.

Seek and destroy 8-oxoguanine

Featured Article - May 2010
A systematic search reveals the first 8-oxoguanine deaminase.

Antibiotics and Ribosome Function

Featured System - March 2010
Antibiotics are often discovered in nature, where they are lethal weapons in the fight between different organisms.

Pseudouridine Synthase TruA

Featured System - November 2009
Evolution is a great tinkerer.

Get3 into the groove

Featured Article - October 2009
Unlike most membrane proteins, SNAREs enter the endoplasmic reticulum after translation. The structure of the ATPase needed for entry reveals the likely mechanism.

Guanine Nucleotide Exchange Factor Vav1 and Rho GTPase Rac1

Featured System - October 2009
Our cells are filled with a cytoskeleton that provides an infrastructure for support, transport, and locomotion.

Proofreading RNA

Featured Article - July 2009
The structure of RNA polymerase II caught in the 'backtracked' state reveals how it ensures faithful transcription.Science 324, 1203-1206 (2009)

Hda and DNA Replication

Featured System - June 2009
Cell division requires careful bookkeeping.

The elusive helicase

Featured Article - April 2009
A combination of NMR, mutagenesis and biochemistry reveals the dynamic nature of the eIF4A/4G/4H helicase complex.Cell 136, 447-470 (2009)

Poly(A) RNA recognition

Featured Article - January 2009
Homodimerization of type II poly(A)-binding proteins prevents binding in the absence of RNA.Proc Natl Acad Sci. USA 105, 15317-15322 (2008)

Scavenger Decapping Enzyme DcpS

Featured System - November 2008
Messenger RNA molecules are temporary molecules.

Bacteriophage Lambda cII Protein

Featured System - October 2008
Living cells are constantly making decisions: when to eat, when to move, even when to die.

RNase T

Featured System - July 2008
Living cells are filled with RNases, but not highly destructive ones like our digestive RNase.

SARS Coronavirus Nonstructural Protein 1

Featured System - June 2008
Researchers at the Joint Center for Structural Genomics have obtained the first look at nsp1 (nonstructural protein 1), a major factor in the pathogenicity of the coronavirus that causes SARS (severe acute respiratory syndrome).
Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health