PSI Structural Biology Knowledgebase

PSI | Structural Biology Knowledgebase
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Cell biology
Drug discovery
Infectious diseases
Membrane proteins
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E-Collection Research Themes: Infectious diseases

Related Articles

Protein Folding and Misfolding: It's the Journey, Not the Destination

Technical Highlight - March 2015
Computational analysis suggests ∼10% of pathogenic mutations interfere with membrane integration.

CCR5 and HIV Infection

Featured System - January 2015
A new PSI structure shows how the anti-HIV drug maraviroc locks the coreceptor CCR5 in an inactive state.

HIV/AIDS: Pre-fusion Env Exposed

Featured Article - January 2015
A crystal structure of the pre-fusion HIV-1 Env captures gp41 and provides insights into immune recognition.

HIV/AIDS: Slide to Enter

Featured Article - January 2015
A sliding hinge in gp41 promotes HIV membrane fusion and viral infection.

Updating ModBase

Technical Highlight - January 2015
An expanded ModBase comparative protein structure database and toolkit enables insights into protein function, including determinants of HIV-1 protease specificity.

Power in Numbers

Featured System - August 2014
PSI researchers have determined the structure of a transcriptional regulator involved in quorum sensing in an important pathogenic bacterium.

Quorum Sensing: A Groovy New Component

Featured Article - August 2014
A first-in-family structure of a Pseudomonas-specific protein provides clues to its role in quorum sensing.

Bacterial CDI Toxins

Featured System - June 2014
PSI researchers have solved the structures of several potent bacterial toxins, along with their antidotes.

Immunity: One Antibody to Rule Them All

Featured Article - June 2014
Structural studies of antibody F045–092 explain its ability to neutralize all H3-subtype influenza strains.

Virology: A Bat Influenza Hemagglutinin

Featured Article - March 2014
The crystal structure of HA antigen from H17N10 bat influenza virus shows how its receptor binding site has diverged from human flu strains.

Virology: Making Sensitive Magic

Technical Highlight - March 2014
Dynamic nuclear polarization is used to enhance the sensitivity of an MAS NMR experiment, allowing detection of inhibitor binding to the M2 proton channel.

Virology: Visualizing Cyanophage Assembly

Technical Highlight - March 2014
The first application of ZPC cryoET provides insight into cyanophage assembly process.

Virology: Zeroing in on HBV Egress

Featured Article - March 2014
Crystal structures of human γ2-adaptin in complex with a peptide from HBV preS1 suggest a path to antivirals.


Featured System - March 2014
PSI researchers have determined the structures of several viral pore-forming proteins, revealing common functional features.

Cas4 Nuclease and Bacterial Immunity

Featured System - February 2014
A distinctive toroidal structure, a metal ion and an iron-sulfur cluster allow Cas4 to unwind and process phage DNA in the process of CRISPR-associated immunity.

Microbial Pathogenesis: A GNAT from Pseudomonas

Featured Article - February 2014
A multidisciplinary approach offers a detailed view of a bacterial acetyltransferase.

Microbial Pathogenesis: Targeting Drug Resistance in Mycobacterium tuberculosis

Featured Article - February 2014
Whole-cell screening for antituberculosis compounds combined with identification of resistance-linked mutations provide novel scaffolds for drug development.

Microbiome: The Dynamics of Infection

Technical Highlight - September 2013
A combination of systems approaches reveals how Salmonella displaces commensal gut bacteria to establish infections.

Membrane Proteome: A Funnel-like Viroporin

Featured Article - August 2013
The NMR structure of HCV p7 channel reveals a funnel-like architecture, providing insight into cation conductance and drug-mediated inhibition.

Infectious Diseases: A Pathogen Ubiquitin Ligase

Featured Article - May 2013
A novel bacterial effector protein functions as a ubiquitin E3 ligase.

Infectious Diseases: A Shared Syringe

Featured Article - May 2013
Tail sheath proteins of one viral family share a common fold and conformational changes despite low sequence identity.

Infectious Diseases: Determining the Essential Structome

Technical Highlight - May 2013
Twenty-five potential drug targets emerge from the Burkholderia structome through an integrated pipeline.

Infectious Diseases: Targeting Meningitis

Technical Highlight - May 2013
Screens with substrates and inhibitors, followed by molecular modeling, reveal details of an enzyme's ligand binding specificity.

NDM-1 and Antibiotics

Featured System - May 2013
With structural biology and computational analysis, PSI Biology researchers have revealed the catalytic pathway of an antibiotic-destroying enzyme.

Bacterial Hemophores

Featured System - January 2013
PSI biology researchers are exploring the proteins that pathogenic bacteria use to gather scarce heme groups, and the iron ions they carry.

Microbial Pathogenesis: Computational Epitope Prediction

Technical Highlight - January 2013
A computational approach uses structural information to identify epitopes within antigenic proteins.

Microbial Pathogenesis: Influenza Inhibitor Screen

Technical Highlight - January 2013
A cell-free binding assay is optimized step by step and applied in high throughput to screen for small molecule inhibitors of an influenza protein.

Microbial Pathogenesis: Measles Virus Attachment

Featured Article - January 2013
The third structure of a host receptor bound to measles virus hemagglutinin pinpoints a hydrophobic lock hole.

Microbial Pathogenesis: NEAT Iron

Featured Article - January 2013
Structural transitions in a bacterial hemophore suggest a mechanism that couples hemoglobin binding and heme capture.

Membrane Proteome: Sphingolipid Synthesis Selectivity

Featured Article - December 2012
Substrate specificity in trypanosomal sphingolipid synthases can be determined by variation in as few as three residues.

A signal sensing switch

Featured Article - September 2012
The structure of the sensor complex for the TMAO receptor sheds light on bacterial two-component signaling.

Gauging needle structure

Featured Article - July 2012
Solid-state NMR and computer modeling yield a highly resolved atomic model of the type III secretion system needle.

Anthrax Stealth Siderophores

Featured System - June 2012
Iron is an essential mineral, used by many enzymes for its ability to trap small molecules like oxygen and to act as a conduit of electron transfer.

A Pseudomonas L-serine dehydrogenase

Featured Article - May 2012
Structural studies of an uncharacterized Pseudomonas aeruginosa enzyme reveal a dehydrogenase with a substrate preference for L-serine.

Pilus Assembly Protein TadZ

Featured System - April 2012
Many bacteria are covered with long filaments, called pili or fimbriae, that help them interact and attach to their environment.

Making Lipopolysaccharide

Featured System - January 2012
Many bacteria surround themselves with a protective coat, to resist attack from antibiotics, predators, and the immune system.

Superbugs and Antibiotic Resistance

Featured System - December 2011
Antibiotics were used as weapons to fight bacteria long before Alexander Fleming discovered penicillin.

A change to resistance

Featured Article - November 2011
Two structures of NDM-1 β-lactamase show how this enzyme can confer resistance to many antibiotics.

An effective and cooperative dimer

Featured Article - November 2011
NMR studies reveal the dimer interface of the effector domain (ED) of NS1A from influenza A virus and provide insight into how dimerization of the ED provides cooperative dsRNA binding and other functions of NS1A.

The Perils of Protein Secretion

Featured System - November 2011
Salmonella bacteria are tiny terrorists that infect cells and ultimately destroy them.

Bacterial Armor

Featured System - October 2011
Bacteria are found in nearly every corner of the world, evolving unique mechanisms to survive in their different environments.

Breaking down the defenses

Featured Article - September 2011
The structure of ISG15 bound to NS1B gives insight into the mechanism by which influenza B virus specifically targets humans.

Moving some metal

Featured Article - August 2011
The crystal structure of a copper-transporting P1B-type ATPase provides valuable insight into how mutations contribute to Menkes' and Wilson's diseases.

Capsid assembly in motion

Technical Highlight - April 2011
Using hydrogen–deuterium exchange, Gag immature, mature and cleavage-mutant particles are now examined to follow the dynamic changes that occur during capsid assembly.

Know thy enemy … structurally

Special - October 2010
Visualizing molecules linked to disease can give insight into how to strike back. All the more reason for aiming to solve structures of these proteins.

Treating sleeping sickness

Featured Article - May 2010
A potential new drug kills the bloodstream parasite that causes this disease.

Bacterial spore kinase

Featured Article - April 2010
A genomic, phylogenetic and structural study hints that these kinases have functional roles that might be druggable.

Hemolysin BL

Featured System - January 2010
Bacteria are master weapon makers.

Unusual cell division

Featured Article - October 2009
Streptomyces' unique mechanism for cell division comes under the spotlight and reveals the importance of the protein SsgB.

Anthrax evasion tactics

Featured Article - September 2009
The crystal structure of a crucial anthrax capsule enzyme will aid the search for new therapies.

Toxin-antitoxin VapBC-5

Featured System - September 2009
Living cells are full of surprises and mysteries.

Antibiotic target

Featured Article - August 2009
An unusual reaction in the production of thymine offers hope for anti-tuberculosis drugs.Nature 458, 919-923 (2009)


Featured System - July 2009
Antibiotics are one of the major triumphs of twentieth century science, but unfortunately, the bacteria are fighting back.

Tackling influenza

Featured Article - June 2009
Structural studies reveal a new target for anti-influenza drugs that should work whatever the influenza virus strain.Nature 458, 909-913 (2009)

You look familiar: the Type VI secretion system

Featured Article - June 2009
New structures raise the perplexing question of which came first, the bacterial secretion system or the bacteriophage tail.Proc. Natl Acad. Sci. USA 106, 4154-4159 (2009)

Unique SARS

Featured Article - April 2009
The solution structure of the SARS unique domain confirms that it binds single-stranded RNA and hints at its function.J. Virol. 83, 1823-1836 (2009)

Anthrax stealth molecule

Featured Article - March 2009
Bacillus anthracis relies on an unusual metabolite to evade human innate immunity and to be fully virulent in the host.Proc. Natl Acad. Sci. USA 105, 17133-17138 (2008)

A new class of bacterial E3 ubiquitination enzymes

Featured Article - January 2009
A structurally and mechanically distinct class of ubiquitin ligases has been discovered, and a single mutation changes this enzyme from a ligase to a potent thioesterase.Nature Struct. Mol. Biol. 15, 1293-1301 (2008)

Antiviral evasion

Featured Article - October 2008
Proc. Natl Acad. Sci. USA 105, 13093-13098 (2008)

SARS connections

Featured Article - September 2008
J Virol 82, 5279-5294 (2008)

SARS Coronavirus Nonstructural Protein 1

Featured System - June 2008
Researchers at the Joint Center for Structural Genomics have obtained the first look at nsp1 (nonstructural protein 1), a major factor in the pathogenicity of the coronavirus that causes SARS (severe acute respiratory syndrome).
Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health