PSI Structural Biology Knowledgebase

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id="title" class="nomar"Enzyme Discovery for Natural Product Biosynthesis

Member Institutions

  • Rice University
  • University of Kentucky
  • The Scripps Research Institute-Florida
  • University of Wisconsin-Madison

Contact Information

George N. Phillips, Jr.
georgep@rice.edu

Research Description

The Natural Product Biosynthesis (NATPRO) was established in July 2011 with the funding of a contract from the National Institute of General Medical Sciences (NIH) entitled Enzyme Discovery for Natural Product Biosynthesis. The goals of NATPRO are to apply technologies developed by the Protein Structure Initiative (PSI) to problems of interest to the community of biologists and biochemists who investigate the role of natural products in human health and disease. The NATPRO will play strong joint roles in both the identification of new natural product pathways and the subsequent discovery of new natural product-based pharmaceuticals by revealing the structures and active sites of novel enzymes, characterizing the enzymatic reactions of the gene products, identifying new natural products, and thus offering opportunities to identify and customize the pathways by altering specificities and/or identifying novel proteins or domains with desired enzymatic properties.

Key Publications

coming soon

Structures, Targets, Publications and Technologies

NatPro Structures in RCSB PDB
NatPro Targets in TargetTrack
NatPro SBKB Publications Page

Relevant Links

Enzyme Discovery for Natural Product Biosynthesis

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health