PSI Structural Biology Knowledgebase

PSI | Structural Biology Knowledgebase
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id="title" class="nomar"GPCR Network

The GPCR Network is a PSI Membrane Protein Structure Determination Center, and consists of investigators from The Scripps Research Institute; University of California, San Diego; Argonne National Laboratory; and The Scripps Research Institute, Florida.

GPCR Network Investigators

  • The Scripps Research Institute
    Raymond C. Stevens
    Vadim Cherezov
    Ellen Y.T. Chien
    Peter Kuhn
    Hugh Rosen
    Kurt Wüthrich
  • University of California San Diego
    Ruben Abagyan
    Vsevolod Katritch
  • Argonne National Laboratory
    Robert F. Fischetti
  • TSRI-Florida
    Patrick Griffin

HT-enabled Structural Biology Partner

Contact Information

Raymond C. Stevens
stevens@scripps.edu

Angela L. Walker
alwalker@scripps.edu

Research Description

Using a protein family specific platform, the GPCR Network will work closely with the GPCR community to determine the high resolution structure and function of GPCRs distributed broadly across the phylogenetic family tree. The easily accessible and open data will create a dynamic and informative GPCR-Network of value to the entire scientific community. Researchers/Scientists interested in collaborating with the GPCR network on a receptor that they are working on should contact us via the link provided below (or stevens@scripps.edu )


Key Publications
  1. E.Y.T. Chien, W. Liu, Q. Zhao, V. Katritch, G. W. Han, M.A. Hanson, L. Shi, A.H. Newman, J.A. Javitch, V. Cherezov, R.C. Stevens, Structure of the Human Dopamine D3 Receptor in Complex with D2/D3 Selective Antagonist, Science, 2010, Nov 19:330(6007)
  2. B. Wu, E.Y.T. Chien, C.D. Mol, G. Fenalti, W. Liu, V. Katritch, R. Abagyan, A. Brooun, P. Wells, F.C. Bi, D.J. Hamel, P. Kuhn, T.M. Handel, V. Cherezov, R.C. Stevens
    Structures of the CXCR4 chemokine receptor in complex with small molecule and cyclic peptide antagonists.
    Science
    , Epub ahead of print 07 Oct 2010 (PubMed ID: 20929726)
  3. V.P. Jaakola, M.T. Griffith, M.A. Hanson, V. Cherezov, E.Y.T. Chien, J.R. Lane, A.P. Ijzerman, and R.C. Stevens.
    The 2.6Å crystal structure of a human A2A adenosine receptor bound to an antagonist.
    Science, 322,1211-1217 (2008) (PubMed ID: 18832607).

  4. V. Cherezov, D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, and R.C. Stevens.
    High resolution crystal structure of human β2-adrenergic G protein coupled receptor.

    Science 318,1258-1265 (2007) (PubMed ID: 17962520).
  5. D.M. Rosenbaum, V. Cherezov, MA. Hanson, S.G. Rasmussen, F.S. Thian, T.S. Kobilka, H.J. Choi, X.J. Yao, W.I. Weis, R.C. Stevens, and B.K. Kobilka (2007) GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function Science Nov23:318(5854): 1266-73. (PMID: 17962519)

Structures, Targets, Publications and Technologies

GPCR Structures in RCSB PDB
GPCR Targets in TargetTrack
GPCR SBKB Publications Page
GPCR SBKB Technology Portal Page

Relevant Links

GPCR Network

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health