PSI Structural Biology Knowledgebase

PSI | Structural Biology Knowledgebase
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id="title" class="nomar"Joint Center for Structural Genomics

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The JCSG is a multi-institutional consortium with major activities at The Scripps Research Institute (TSRI); the Genomics Institute of the Novartis Research Foundation (GNF); the University of California, San Diego (UCSD); the Sanford-Burnham Medical Research Institute (Sanford-Burnham); and the Stanford Synchrotron Radiation Lightsource (SSRL), SLAC National Accelerator Laboratory, at Stanford University.

Contact Information

Ian A. Wilson, PI
wilson@scripps.edu

Scott Lesley, Crystallomics Core Leader
slesley@gnf.org

Adam Godzik, Bioinformatics Core Leader
adam@sanfordburnham.org

John Wooley, Bioinformatics Core Project Director
jwooley@ucsd.edu

Ashley Deacon, Structure Determination Core Leader
adeacon@slac.stanford.edu

Kurt Wüthrich, NMR Core Director
wuthrich@scripps.edu

Research Description

The Joint Center for Structural Genomics (JCSG) high-throughput (HT) platform assembled over the past ten years can efficiently deliver large numbers of protein structures to the community by both x-ray crystallography and NMR on a wide range of targets from bacteria to human, including challenging targets, such as eukaryotic proteins, protein-protein and other macromolecular complexes. Our primary mission in PSI:Biology is to provide a robust, flexible HT structure determination platform that will meet the challenges and embrace the new opportunities that arise from the projects emanating from the PSI:Biology Partnerships, future PARS, and the community, as well as actively engage in other PSI Network activities, including the PSI-SBKB and PSI-MR. The JCSG will leverage its HT platform to promote the biological and biomedical impact of all of its structures through extensive biophysical, functional and bioinformatics analyses in collaboration with the other PSI:Biology participants. Thus, we can capitalize on our extensive experience to develop the best strategies to enhance chances of success and eliminate those that lead to failure. Furthermore, we will strive along with the PSI Network to promote widespread use of the PSI resources, materials, methodologies, data and models to the general scientific community. The JCSG will continue to develop new technologies and methodologies, both experimental and computational, to address the spectrum of targets that will be presented, while keeping cost per structure to a minimum and quality to the highest standard. We will also continue to contribute to the original PSI mission of extending structural coverage of the expanding protein universe. Our biomedical theme project in PSI:Biology will focus on the human microbiome. Interactions of commensal bacteria with the human body are profound and have a significant impact on maintenance of general human health, as well as being associated so far with obesity, inflammatory diseases, diabetes and certain cancers.

 

Key Publications
  1. Joint Center for Structural Genomics (JCSG) special issue, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10) See link to 35 articles: http://journals.iucr.org/f/issues/2010/10/00/issconts.html 

  2. Jaroszewski L, Li Z, Krishna SS, Bakolitsa C, Wooley J, Deacon AM, Wilson IA, Godzik A (2009)
    Exploration of uncharted regions of the protein universe.

    PLoS Biology, 7, e1000205 (PubMed ID: 19787035)
  3. Zhang Y, Thiele I, Weekes D, Li Z, Jaroszewski L, Ginalski K, Deacon AM, Wooley J, Lesley SA, Wilson IA, Palsson B, Osterman A, Godzik A (2009)
    Three-dimensional structural view of the central metabolic network of Thermotoga maritima.

    Science, 325, 1544-9 (PubMed ID: 19762644)
  4. Weekes D, Krishna SS, Bakolitsa C, Wilson IA, Godzik A, Wooley J (2010)
    TOPSAN: a collaborative annotation environment for structural genomics.

    BMC Bioinformatics, 11, 426  (Pub Med ID: 20716366)

  5. Slabinski L, Jaroszewski L, Rychlewski L, Wilson IA, Lesley SA, Godzik A (2007)
    XtalPred: a web server for prediction of protein crystallizability.

    Bioinformatics, 23(24), 3403-5  (Pub Med ID: 17921170)

 

Structures, Targets, Publications and Technologies

JCSG Structures in RCSB PDB
JCSG Targets in TargetTrack
JCSG SBKB Publications Page
JCSG SBKB Technology Portal Page

Relevant Links

Joint Center for Structural Genomics homepage
TOPSAN (Collaborative Wiki)
XtalPred (Crystallization Prediction)
JCSG Ligand Server (PSI Structures)
JCSG QC Server (Structure Validation)
JCSG Crystallographic Datasets Repository

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health