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id="title" class="nomar"Mitochondrial Protein Partnership

First Row (L to R): Marley Crews-Hill, Trang Nguyen, Rachel Schwanz, Andrew Gesior, Nicole Reinen, Fabian Suchy, Jakki Saunders. Second Row: Leah Schmitz, Jon Stefley, Kylie Moyer, Emily Beebe, Tina Misenheimer, Hannah Meddaugh. Third Row: John Markley (MPP PI), John Primm (Project Manager), Brian Fox (TMPC PI), Shin-ichi Makino, Otto Kletzien. Back Row: David Pagliarini (MPP PI), Ronnie Frederick, Andrew Reidenbach, Russell Wrobel, Dave Aceti, Don Drott, Jameson Bothe. (Not Pictured: Kasia Gromek and Donna Troestler)

The MPP is composed of investigators from the University of Wisconsin-Madison. It is partnered with the PSI High-Throughput Structure Determination center NESG

MPP Investigators

  • University of Wisconsin-Madison
    John Markley, PI
    Dave Pagliarini, Co-PI
    Craig Bingman
    Brian Fox
    George Phillips, Jr.

Contact Information

John Markley, PI
markley@nmrfam.wisc.edu

Dave Pagliarini, Co-PI, target nominations and collaborations
pagliarini@wisc.edu

John Primm, other matters
jgprimm@wisc.edu

Research Description

The goals of the Mitochondrial Protein Partnership (MPP) are to apply technologies developed by the Protein Structure Initiative (PSI) to problems of interest to the community of biologists and biochemists who investigate the role of mitochondria in human health and disease. The mitochondrial proteome contains many ORFs, or domains of ORFs, that meet the PSI’s criterion of “uniqueness” (low sequence similarity to proteins of known structure), many ORFs of major biomedical importance currently unrepresented by three-dimensional structures, and many proteins that lack functional characterization. The MPP solicits nominations from the scientific community for mitochondrial protein targets of biological/biomedical interest that would be suitable for collaborative study. Once nominations have been approved, collaborative arrangements have been set up, these targets are given high priority, and collaborators are informed of progress made in producing and characterizing the protein in determining structures. The Northeast Structural Genomics (NESG) Consortium is partnering with the MPP as its engine for high-throughput structure determination. The MPP itself focuses on functional investigations of mitochondrial proteins, including protein-protein and protein-small molecule interactions, enzymatic analyses, and mitochondrial import assays. Successful collaborations are expected to lead to joint publications.

Mentions at PSI Structural Biology Knowledgebase

Protein Interaction Networks: Morph to Assemble

Relevant Links

Mitochondrial Protein Partnership
Center for Eukaryotic Structural Genomics (PSI-2)
Center profile in Technology Portal

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health