PSI Structural Biology Knowledgebase

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id="title" class="nomar"New York Structural Genomics Research Consortium

The PSI High-Throughtput Structure Determination center NYSGRC is a multi-institutional network of investigators at Albert Einstein College of Medicine; Brookhaven National Laboratory; University of California, San Francisco; University of Virginia; and University of Washington.

NYSGRC Investigators

Steven C. Almo, PI

Andras Fiser, Co-PI

S. Swaminathan, Co-PI

Andrej Sali, Co-PI

Wladek Minor, Co-PI

David Baker, Co-PI

Ronald D. Seidel III, Director of Protein Production

Jeffrey B. Bonanno, Project Manager

Research Description

The NYSGRC, lead by Steven Almo and composed of additional investigators from Einstein, Brookhaven National Laboratory, University of Virginia and UCSF, is one of four high-throughput production centers for the NIH NIGMS Protein Structure Initiative (PSI). During the current five year phase of the program (PSI:Biology, 2010 to 2015), the general scope of grant activities includes high-throughput protein expression, crystallization, and structure determination, with an emphasis on addressing the challenges associated with eukaryotic proteins and complexes. This infrastructure will enable the research activities of a base of collaborating biologists from the NIH PSI Network and also from the broader biological research community. These researchers nominate protein targets of significant biological interest and the production centers generate reagents (including expression clones and purified proteins) and X-ray crystal structures to facilitate investigations into the biological activity of the targets.

Currently, the NYSGRC is partnered with two PSI:Biology U01 Consortia for High-Throughput-Enabled Structural Biology Partnerships which have nominated broad protein target lists in the areas of immune response and cell adhesion. The NYSGRC is now actively pursuing these targets as well as its own internal targets from the area of bacterial secretion apparati and effectors. The NYSGRC and its partner centers have also established numerous additional collaborations with a wide range of scientists including enzymologists, bacteriologists, immunologists, bioinformaticians, and cryo-EM spectroscopists in which materials and information generated for target proteins will be actively shared to leverage the work product of the PSI.

Relevant Links

The New York Structural Genomics Research Consortium Homepage

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health