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id="title" class="nomar"Northeast Structural Genomics Consortium

The PSI High-Throughtput Structure Determination center NESG is a multi-institutional network of investigators at Rutgers, The State University of New Jersey; Columbia University; Miami University; Robert Wood Johnson Medical School, UMDNJ; Technical University of Munich; The State University of New York at Buffalo; Hauptman Woodward Research Instititute; University of Toronto; and University of Georgia.

Member Institutions

  • Rutgers, The State University of New Jersey
    Gaetano T. Montelione, Ph.D.
    Stephen Anderson, Ph.D.
  • Columbia University
    Barry Honig, Ph.D. John Hunt, Ph.D.
    Wayne Hendrickson, Ph.D.
    Diana Murray, Ph.D.
    Liang Tong, Ph.D.
  • Miami University
    Michael Kennedy, Ph.D.
  • Robert Wood Johnson Medical School, UMDNJ
    Masayori Inouye, Ph.D.
    Nancy Woychick, Ph.D.
  • Technical University of Munich
    Burkhard Rost, Ph.D.
  • The State University of New York at Buffalo
    Thomas Szyperski, Ph.D.
  • Hauptman Woodward Research Instititute
    George DeTitta, Ph.D.
  • University of Toronto
    Cheryl Arrowsmith, Ph.D.
  • University of Georgia
    James Prestegard, Ph.D.

Contact Information

Gaetano T. Montelione
guy@cabm.rutgers.edu

John Everett
everett.jk@gmail.com

Research Description

The Northeast Structural Genomics (NESG) consortium is one of the four large scale NIH funded structural genomics centers of the NIGMS Protein Structure Initiative - Biology program

The NESG employs both X-Ray Crystallography and NMR Spectroscopy to determine the three-dimensional structures of novel proteins. NESG protein structures provide novel structural information useful in modeling thousands protein domains.

Targeted proteins are typically representatives from large protein domain families, biomedical themes, and targets nominated by the biomedical community. The NESG focuses on eukaryotic proteins, particularly human proteins involved in cancer biology, protein-protein interaction networks, specific biochemical pathways, and proteins implicated in other human diseases.

PSI HTP-Enabled Biology Projects that are collaborating with the NESG include the Mitochondrial Proteome Project - MPP (Markley et al) and Epigenetics of Eukaryotic Gene Regulation (Kossiakoff et al.). These projects, together with the Human Cancer Protein Interaction Network biological theme project of the NESG, provide a strong focus on eukaryotic structural genomics.

Structures determined by the NESG and other structural genomic groups are an essential component of biological research, often providing tests of specific biological hypotheses. Structural genomics is not driven by specific hypotheses but rather often provides critical clues to biochemical function and evolutionary processes and thus is often a "hypothesis generating" activity.

The technologies, structures, and reagents developed by the NESG and the PSI provide the basis for new hypothesis-driven research projects.

Relevant Links

Northeast Structural Genomics Consortium homepage
SPINE NESG Target Database
NESG Structure Gallery
Human Cancer Protein Interaction Network
NESG Web Servers and Tools
NESG Structure Production Statistics
NESG Technology Development
NESG Community Nominated Targets
NESG Databases
Center profile in Technology Portal

Structural Biology Knowledgebase ISSN: 1758-1338
Funded by a grant from the National Institute of General Medical Sciences of the National Institutes of Health