id="title" class="nomar"Partnership for Stem Cell Biology
This biological project is composed of investigators from the University of California, San Francisco, The Methodist Hospital Research Institute, and the Gladstone Institutes, and is partnered with the PSI High-Throughput Structure Determination center JCSG.
Robert Fletterick, PhD
Paul Webb, PhD
Bruce Conklin, MD
Stem cells differentiate into new cell types or remain renewable. Transcription factors regulate the processes that determine cell fate. Our program will determine structures of assemblies of proteins and DNA that determine fates of stem cells. Recent discoveries suggest that non stem cells such as fibroblasts can be manipulated by activation of a few stem cell transcription factors to become induced pleuripotent stem cells which have some characteristics of pleuripotent stem cells. These cells may be differentiated to acquire new fates. With the Joint Center for Structural Genomics, structures will be determined for transcription factor machines