2009 NIGMS Workshop - Enabling Technologies for Structural Biology
|
March 4-6, 2009 |
|
| Wednesday, March 4 |
|
| 07:15am |
Registration, Refreshments and Poster Setup |
| 07:55am |
Opening Remarks - John Norvell and Jeremy Berg |
| _____________ |
|
| Session I |
Protein-Protein Interactions and Complexes |
| Chair Celia Goulding |
|
| 08:00am |
Keynote Lecture: Professor Michael Rossmann, Purdue University, The Limits of Crystallography Mark The Beginnings Of Biology: Structural Studies of Viral Pathogens (01_Rossmann.ppt) |
| 08:50am | Donald Petrey, Structural Alignment in Predicting Protein-Protein Interactions (02_Petrey.ppt) |
| 09:15am |
Li-Chung Ma, Structural Biology of Influenza Viruses - Applications of Technologies From Structural Genomics |
| 09:40am |
20 minute Coffee Break and Poster Viewing |
| Session II |
Protein-Protein Interactions and Complexes (continued) |
| Chair Celia Goulding | |
| 10:00am | Carthene Bazemore-Walker, Identification of Sigma-1 Receptor Post-translational Modifications and Interacting Proteins Using Chemical Proteomics (04_Bazemore-Walker.pdf) |
| 10:25am |
Qiang Wang, MOLIDE2: Homology Modeling or Protein Oligomers and Complexes (05_Wang.ppt) |
| 10:50am |
Marc Deller, Structural Dissection of the Pentose Phosphate Pathway Of Thermatoga maritima |
| 11:15am |
Hunjoong Lee, Skyline as a Discovery Tool for Phosphoinositide-Binding Proteins |
| 11:40am |
Lunch |
| Open Poster Session |
|
| 1:00pm - 7:00pm |
|
| Session III |
Traditional Bottlenecks |
| Chair: Geoff Waldo |
|
| 01:00pm |
Igor Jurisica, PSI Target Prioritization, Cancer Target Selection And Interpretation Using Protein-Protein Interaction Prediction and Analysis (08_Jurisica.ppt) |
| 01:25pm | Samuel Handelman, The CRSH Database: Functional Classification of PSI Proteins to Support High Throughput Biochemical Characterization (09_Handelman.ppt) |
| 01:50pm | Robert Thorne, Slow Cooling for Protein Cryocrystallography |
| 02:15pm | M. Gordon Joyce, A Rational Approach for Heavy Atom Derivatization Of Macromolecules |
| 02:40pm | Yao Fan, Enhanced Crystal Packing Due To Solvent Reorganization Through Reductive Methylation |
| 03:05pm | 25 Minute Coffee Break and Poster Viewing |
| Session IVa |
Tutorials on Structure Methods |
| Chair: Michael Malkowski |
|
| 03:30pm |
High Throughput Crystallization Screening and Optimizationl Deriving Information to Guide Successive Experiments, presented by Joseph R Luft. (13_Luft.ppt) The Center for High-Throughput Structural Biology - Crystallographic Data Collection Facilities at SSRL, presented by A.E. Cohen, S. M. Soltis & the SMB Group at SSRL. The Microcapillary Protein Crystallization System(MPCS): A Methods Tutorial, presented by Cory Gerdts. (abstract)(15_Gerdts.ppt) Semi-Automatic Structure Solution with HKL-3000, presented by W Minor. (abstract)(16_Minor.ppt) |
| Session IVb |
Methods Tutorials on Structural Analysis |
| Chair: Helen M. Berman |
|
| 03:30pm |
How to Use the Protein Structure Initiative Structural Genomics Knowledgebase for Research, presented by Helen M. Berman and Margaret J Gabanyi. (abstract)(17_Gabanyi_pt1.ppt)(17_Gabanyi_pt2.ppt) Modeling for Molecular Replacement, presented by Adam Godzik, Sri Krishna & Constantina Bakolitsa. (abstract) Getting the Most from Your Structure, presented by Adam Godzik, Sri Krishna & Constantina Bakolitsa. (abstract) |
| 05:30pm |
Session IV Close |
| Standby Poster Session |
|
| 05:30pm |
Authors of odd-numbered posters standby |
| 06:15pm |
Authors of even-numbered posters standby |
| 07:00pm |
Poster Session Close |
| Conference Dinner |
|
| 07:30pm |
Bethesda area restaurant to be named |
| Thursday, March 5 |
|
| 07:17am |
Refreshments and Poster Viewing |
| Session V |
Protein Function |
| Chair: Brian Fox |
|
| 08:00am | Keynote Lecture, Professor Frank Raushel, Texas A&M University, Deciphering Substrate Specificity of Enzymes of Unknown Function |
| 08:50am |
Markus Fischer, MarkUs: A Function Annotation Server for Protein Structures (20_Fischer.ppt) |
| 09:15am |
Tonya Silkov, Structural Characterization and Functional Annotation of the Novel Families of Membrane-Binding Proteins |
| 09:40am |
20 minute Coffee Break and Poster Viewing |
| Session VI |
Protein Function (continued) |
| Chair: Brian Fox | |
| 10:00am |
T. Andrew Binkowski, Protein Surface Analysis For Function Analysis and Prediction (22_Binkowski.ppt) |
| 10:25am |
David Aceti, A "Control Workgroup" Of 24 Protein Targets Used to Test Platform Changes (23_Aceti.ppt) |
| 10:50am | Ying Zhang, Metabolic Docking - from Structural Genomics to Functional Genomics (24_Zhang.pdf) |
| 11:15am |
John Hunt, Towards Structurally Enabled High-Throughput Function Elucidation |
| 11:40am |
Lunch |
| Open Poster Session |
|
| 1:00pm - 7:00pm |
|
| Session VII |
Problems and Solutions |
| Chair: Ashley Deacon |
|
| 01:00pm |
Geoffrey S. Waldo, Fluorescent Protein Toolbox: Application To Structural Genomics And Cell Biology |
| 01:25pm | Stephen Anderson, Extra-Cellular Mammalian Proteins As Structural Genomics Targets (27_Anderson.ppt) |
| 01:50pm | Mark Knuth, Application of Medium Scale Robotics for Eukaryotic Cell Expression, Purification And Analysis to PSI Targets |
| 02:15pm |
Vadim Cherezov, New LCP Technologies for Structural Studies of Membrance Proteins |
| 02:40pm |
Lee Makowski, Characterizing the Unsolved Proteins of the PSI using WAXS |
| 03:05pm |
25 minute Coffee Break and Poster Viewing |
| Session VIa |
Methods Tutorials on High-Throughput Purification |
| Chair: Celia Goulding |
|
| 03:30pm |
Semi-Automated High Throughput Protein Purification for Structural Biology, presented by YC Kim. (abstract)(31_Kim.ppt) Improving Protein Crystallization using Protein Reductive Methylation, presented by YC Kim. (abstract) Simple Methods for Monitoring Protein State and Protein Sample Composition by NMR and Light Scattering Measurements, presented by Innokentiy Maslennikov. (abstract) |
| Session VIb | Methods Tutorials on Expression of Proteins |
| Chair: Brian Fox |
|
| 03:30pm | Hands-on Demonstartion of Wheat Germ Cell-free Translation, presented by Shin-Ichi Makino. (abstract)(34_Makino.ppt) Cell-free Expression of Integral Membrane Proteins, presented by Christian Klammt. (abstract)(35_Klammt.ppt) Condensed Single Protein Production (cSPP) of Isotope-Enriched Soluble and Membrane Proteins for Structural Studies, presented by Masayori Inouye. (abstract) |
| 05:30pm |
Session Close |
| Standby Poster Session |
|
| 05:30pm |
Authors of odd-numbered posters standby |
| 06:15pm | Authors of even-numbered posters standby |
| 07:00pm |
Poster Session Close |
| Friday, March 6 | |
| 07:15am |
Refreshments and Poster Viewing |
| Session VIII |
Promoted Talks |
| Chair: Gaetano Montelione |
|
| 08:00am |
Thomas Szyperski, Compiling and Sharing Experience in Research Networks Using 'Wikis' - An Approach for the NESG NMR Section |
| 08:25am | Antonio Rosato, The eNMR Platform for Structural Biology (38_Rosato.ppt) |
| 08:50am |
Yuanpeng Huang, HTP Construct Optimization using Bioinformatics Coupled with an Amide Hydrogen Deuterium (HDX) and HTP NMR Screening (39_Huang.ppt) |
| 09:15am |
Chad Rienstra, Protein Structure Determinzation By Magic-Angle Spinning NMR (40_Rienstra.ppt) |
| 09:40am |
Srivatsan Raman, Predicting Protein Structures to Atomic-Level Accuracy Using Limited NMR Data (41_Raman.pdf) |
| 10:05am |
20 minute Coffee Break and Poster Take-Down |
| 10:25am |
Steven Almo, Atoms to Animals: Structural And Functional Genomics of Immunity |
| 10:50am |
Kemin Tan, The Structure and Function of alpha-Glucosidase from Human Gut Bacterium Ruminococcus obeum (43_Tan.ppt) |
| 11:15am |
Bart Staker, Ligand Screening At the Seattle Structural Genomics Center for Infectious Disease (SSGCID) |
| 11:40am |
Gaetano Montelione, Structural Genomics after 2010 (45_Montelione.ppt) |
| 12:05pm | Closing Statements |
| 12:20pm |
Lunch - Organizers Final Meeting |
