Biomedical themes in PSI:Biology
The third phase of the Protein Structure Inititaive, PSI:Biology, will support research partnerships between groups of biologists and high-throughput structure determination centers to solve problems of biomedical importance.
High-Throughput Structure Determination Centers
Joint Centers for Structural Genomics (JCSG): Human microbiome: Interactions of commensal bacteria with the human body are profound and have a significant impact on maintenance of general human health, as well as being associated so far with obesity, inflammatory diseases, diabetes and certain cancers.
Midwest Center for Structural Genomics (MCSG): Various themes: proteins associated with virulence in human pathogens, proteins overrepresented and associated with disease in human microbiomes and proteins involved in signaling and transcription regulation - areas we are already pursuing in collaboration with leaders in the scientific community.
NorthEast Structural Genomics consortium (NESG): Eukaryotic proteins: particularly human proteins involved in cancer biology, protein-protein interaction networks, specific biochemical pathways, and proteins implicated in other human diseases.
New York Structural Genomics Research Consortium (NYSGRC): NIAID Category A, B and C pathogens: the entire ensemble of secreted molecules and their associated secretion apparati as well as a wide range of bacterial essential gene products and orthologs of FDA-approved drug targets.
Membrane Protein Structure Determination Centers
MPSBC Membrane Protein Structure Biology Consortium
MPbyNMR Membrane Protein Structure by Solution NMR
TEMIMPS Transcontinental EM Initiative for Membrane Protein Structure
TMPC TransMembrane Protein Center
Structural Genomics-focused Centers
CSMP Centers for Structures of Membrane Proteins
MPID Center for Membrane Proteins in Infectious Diseases
NYCOMPS New York Consortium on Membrane Proteins Structure
Specific Protein Family focused Centers
TransportPDB Human Transporters
GCPR Network Human G Protein-Coupled Receptors
Each of the HTP-enabled structural biology partnerships focus