Membrane proteins play key roles in controlling the processes of life. The Protein Structure Initiative is targeting this notoriously difficult class of proteins to fast-track discovery and enhance medicine and biology.
A practical guide to cloning, expressing, purifying and crystallizing membrane proteins. Nat. Protoc. 4, 619-637 (2009)read more
The pentameric ligand-gated ion channels (pLGICs) are known to be affected by alcohol in eukaryotes. Analyses of the prokaryotic GLIC suggest that it may be a good structural model for the effects of n-alcohols on pLGICs.read more
An easy-to-use chemical approach for stabilizing, extracting and crystallizing integral membrane proteins.read more
An innovative method combines NMR experiments and a database search to determine the structure of a challenging membrane protein.read more
The crystal structure of a copper-transporting P1B-type ATPase provides valuable insight into how mutations contribute to Menkes' and Wilson's diseases.read more