Membrane proteins play key roles in controlling the processes of life. The Protein Structure Initiative is targeting this notoriously difficult class of proteins to fast-track discovery and enhance medicine and biology.
The NMR structure of HCV p7 channel reveals a funnel-like architecture, providing insight into cation conductance and drug-mediated inhibition.read more
All PSI Membrane Protein Structure Centers and one large-scale production center have joined forces to create a strategy to maximize our understanding of the human transmembrane proteome.read more
Crystal structures of 5-HT receptors bound to antimigraine drugs offer insights into ligand specificity and signaling bias.read more
Molecular docking models are combined with in vitro and in vivo assays to evaluate the therapeutic potential of 6-nitroquipazine analogs as antidepressants.read more
A structural model of the norepinephrine transporter is used in a virtual ligand screen to identify new drug interactions.read more