Midwest Center for Structural Genomics (MCSG)
The objective of the Midwest Center for Structural Genomics (MCSG) is to develop and optimize new, rapid, integrated methods for highly cost-effective determination of protein structures through X-ray crystallography. The near-term goal is to provide the technological basis for rapid elucidation of the remaining repertoire of fundamental protein structures, a concept made possible by the emerging comprehensive genomic data and the data generation capacity of third-generation synchrotrons and advances in computer science and technology. Achieving this goal requires enhancement of all the methods involved in protein production, crystal growth, structure determination, and structural model generation and refinement. Success will be based on introduction of highly parallel execution of experimental protocols. This approach will have broad and long-lasting importance to much biomedical research as well as for its immediate goal of facilitating the development of the new discipline known as structural genomics. We plan to solve quickly large number of "easy" targets, in the process develop new, more advanced tools, methods and approaches that can be applied to "unsolved and difficult projects".