The Protein Structure Initiative is organized in a collection of Large-Scale, Specialized, Modeling and Resource Centers. Brief summaries of the centers and links to the center websites are available from the items in the left menu and the text below.
Large Scale Centers
Four large-scale centers, all established during the PSI pilot phase, have constructed structural genomics pipelines for the production and structural determination of proteins in a high-throughput operation. Over the 5-year period of PSI-2, these centers will coordinate their efforts to generate more than 4,000 structures of protein families, thus meeting the programs goals of increasing structural coverage of sequenced genes and providing benefits for the entire biomedical community. The centers will also develop new technologies to improve the pipeline and to increase success rates and lower costs. Each center also has an individual structural genomics research project, as described in the menu items for each center.
- Joint Center for Structural Genomics
- Midwest Center for Structural Genomics
- Northeast Structural Genomics Consortium
- New York SGX Research Center for Structural Genomics
Six specialized centers are developing innovative methods, approaches, and technologies for producing and determining the structures of proteins that traditionally have been difficult to study. These include small protein complexes, membrane proteins, and proteins from higher organisms including humans. During the next 5 years, these efforts are expected to overcome bottlenecks in the structural genomics pipeline and approach high-throughput operation. The specialized centers are also expected to determine a significant number of these challenging protein structures.
- Accelerated Technologies Center for Gene to 3D Structure
- Center for Eukaryotic Structural Genomics
- Center for High-Throughput Structural Biology
- Center for Structures of Membrane Proteins
- Integrated Center for Structure and Function Innovation
- New York Consortium on Membrane Protein Structure
Two homology modeling centers are developing innovative computational methods for reliably predicting the three-dimensional structures of proteins. This effort brings the PSI closer to its long-range goal of making it easy to determine the shapes of proteins from genetic sequence information. The centers will use PSI structures solved experimentally to help develop computational methods and verify model accuracy.
- Joint Center for Molecular Modeling
- New Methods for High-Resolution Comparative Modeling
Two centers have been established to centralize resources developed by the PSI centers and increase the scientific community's access to them.
The PSI Material Repository is hosted at the Biodesign Institute at Arizona State University. This facility stores and ships PSI-generated clones which can be used to make specific proteins for studies on their structure and function.
This web portal, the PSI Structural Biology Knowledgebase, is hosted by Rutgers University and serves as a central resource for structural information generated by the PSI centers. For every protein, scientists will be able to find the best available information about its structure, biological function, and experimental determination.