GPCR subunits: Separate but not equal
A functional complementation assay reveals that maximal heterotrimeric G-protein activation is achieved by agonist binding to one subunit of a dopamine D2 receptor dimer.
Anthrax evasion tactics
The crystal structure of a crucial anthrax capsule enzyme will aid the search for new therapies.
Mass spectrometers on a chip
A prototype for a mass spectrometer with single-molecule sensitivity has prospects for single-cell proteomics.
Chemical biology: Branching out into chemical space
'Scaffold Hunter' is a computer-based tool that identifies several new ligands that are associated with biochemical activity.
The future of NMR
With the time needed to solve structures by NMR spectroscopy reduced to weeks or even days, how much better can NMR get?
The researchers who published the Ebola virus glycoprotein structure explain how to successfully express, purify and crystallize glycoproteins.