PSI Structural Biology Knowledgebase

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this month's highlights

Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.

September 2010

Special

Introduction
PSI JCSG center director Ian Wilson introduces the third in a series of articles highlighting the achievements of the PSI in 2005–2010.

 

Achievements and milestones
Achievements in protein structure determination in the past five years have provided clues to the evolutionary, structural and functional relationships among proteins that are not evident from sequence data alone.

 

Membrane protein structures enter an exponential growth phase
Adrenergic receptors, ion channels and membrane transport proteins are among the membrane proteins whose structures have recently been determined.

 

Scaling up: single organisms and metagenomics
Structural genomics and systems biology combine forces to uncover the central metabolic network of Thermotoga maritima.

 

Protein pathways
Structural characterization can reveal interaction interfaces between the proteins in a pathway and give insight into potential therapeutics.

 

A journey into the expanding protein universe
By providing new structural knowledge, PSI-2 has covered considerable ground in characterizing protein space.

 

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