Biochemical, structural and genetic analyses reveal that the E. coli Cas1 protein YgbT belongs to a novel family of nucleases and that, in addition to antiviral immunity, the CRISPR–Cas system functions in DNA repair.
A glimpse of NDRG2
While the NDRG family has been implicated in a number of diseases and cancers, the molecular function of these factors remains unclear. The structures of NDRG2 reveal unusual features that give insight into these functions.
SAS-6 forms homodimers mediated by its coiled-coil domain in order to govern centriole formation, according to two new studies.
Two studies reveal new insights into O-GlcNAc and clathrin functions.
One at a time
A trio of new approaches pushes forward the utility of single-molecule imaging.
Capsid assembly in motion
Using hydrogen–deuterium exchange, Gag immature, mature and cleavage-mutant particles are now examined to follow the dynamic changes that occur during capsid assembly.