PSI Structural Biology Knowledgebase

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this month's highlights

Synopses of important developments in the field of structural biology and structural genomics, including advances from the Protein Structure Initiative. The featured articles and technical highlights are specially written for the Structural Biology Knowledgebase, while the research highlights are taken from NPG publications.

May 2012

featured articles

Methyl maintenance
A structure of a DNA methyltransferase complex highlights how autoinhibitory and active mechanisms ensure substrate selectivity.


A Pseudomonas L-serine dehydrogenase
Structural studies of an uncharacterized Pseudomonas aeruginosa enzyme reveal a dehydrogenase with a substrate preference for L-serine.


research highlights

A glimpse at toxicity
A crystallographic study provides a structural model for toxic amyloid oligomers.


Bacterial secretion: Highly sprung secretion
Cryo-electron tomography reveals the contractile sheath structure of a T6SS.


technical highlights

EM for the (small) masses
A new strategy using Fabs allows visualization of small protein molecules by cryoEM.


EM-proving protein structures
A new version of EM-Fold combines medium-resolution data with computational techniques to achieve atomic resolution structures.


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